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At the same time, broad activity can make mechanism assignment more difficult because different tissues may produce similar outcomes through different intermediate pathways
This is why boosting GSH levels and keeping the GSH:GSSG ratio high is essential for maintaining long-term cellular health
The cloning of GPX1 has led to the identification of a specific eukaryotic Sec insertion sequence (SECIS) element as a stem-loop structure located in the 3 untranslated regions (UTR) of the glutathione peroxidase mRNAs
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